Fireworks
The official home of adobe fireworks cs3, adobe's leading vector and bitmap image creation and editing software. perfect for rapid prototyping of web designs, graphics, and layouts.
http://www.macromedia.com/software/fireworks/
Flash
The official home of adobe flash cs3 professional, formerly macromedia flash 8, the industry leading interactive content creation tool. buy or try free here.
http://www.macromedia.com/software/flash
Rhino 3D
3-d modeling for designers
http://www.rhino3d.com/
Xara 3D
Xara is renowned for making quality graphics software for professionals and novices at a price which won't break the bank
http://www.xara.com/